I have SLE which affects my lungs, CNS(central nervous system), and fibromyalgia. I was an employee in an ED but had to quit working due to Lupus. I became bipolar from neuropsychiatric lupus but thank God this resolved with therapy. My advice is all generic plaquenils are NOT the same. I prefer the Prasco brand found at Wal-mart. I am also on methotrexate.(and prednisone for flares) It took 4 years to nail down the diagnosis. the first ANA was negative. I had such enlarged lymph nodes and inflammation in my lungs that in 2005 a spiral CT of the chest with contrast essentially showed lung cancer. It was all due to lupus but since no bronchial washings were performed the diagnosis of lupus was not made until a year later.