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bw915

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 #1 
Hi Everyone,

I am new to this board.  I went to my rheumatologist yesterday to discuss results of my testing for lupus and other autoimmune disorders.  At the visit, she said with my results, she would just term it ANA positive or possibly mixed connective tissue disease, but that she didn't think I met the criteria for lupus diagnosis yet.  My test results were:

SSA Autoantibody8 [AU]/mL0 - 99 [AU]/mL
SSB Autoantibody8 [AU]/mL0 - 99 [AU]/mL
Smith Autoantibody33 [AU]/mL0 - 99 [AU]/mL
RNP Autoantibody12 U/ML0 - 99 U/ML
SCL-70 Autoantibody8 [AU]/mL0 - 99 [AU]/mL
JO-1 Autoantibody18 [AU]/mL0 - 99 [AU]/mL
Double Stranded DNA Ab2 iU/mL0 - 99 iU/mL
Centromere antibody5 [AU]/mL0 - 99 [AU]/mL
Histone antibody8 [AU]/mL0 - 99 [AU]/mL

My value is the first column and the standard range is 0-99, so it looks like all values are within normal limits, however I read on the Lupus Foundation site, and in other books I've read that the presence of the Smith autoantibody almost always indicates that you have lupus.  My symptoms seem to correlate with lupus, and I've been through so much testing and looking for a diagnosis.  I guess I am wondering what other people's test results have been like.  Have they all been higher values than this? Should I seek a second opinion?

Thanks, bw915


Robinj

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 #2 
Welcome :)
Unfortunately, labs are different for every one. I think the main issue would be if your doc is going to treat your symptoms, whether it's lupus or MCTD, etc..
The treatment is the same pretty much. Does your doc have other lupus patients? Has she offered treatment? There are many AI diseases that mimic lupus, so it is hard to comment not knowing your full history.


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bw915

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 #3 
Hi Robinj,

Thanks for your help.  My doctor did offer medication for joint pain, but the symptoms that bother me are mainly neurological.  My neurologist thinks I may have CNS lupus, because they have ruled out all other neurological causes, but the rheumatologist only said to wait and see if the neurological symptoms come back, so it makes me nervous.  When I have a flare it starts with something similar to stroke symptoms, so I'm not sure how much damage it's causing...


Smith&Lesson

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Posts: 465
 #4 
Hi BW!

Welcome, and sorry you have to be here!  We are always happy to add new members to our family though, as Lupus and all Auto-immune diseases can leave you feeling pretty lonely at times. <3  I was diagnosed with SLE based on my symptoms and a very high Anti-Sm.  Looking at the info you provided made me go search for specifics regarding these lab results, and I believe you are still considered NEGATIVE for Anti-Smith.  Labs can vary in their testing, but from a quick search online and viewing my own reports, 0-99 means Negative (and that also fits the Standard Range you provided).  [I was at 490.]

Here are the reference ranges for Anti-Sm according to my lab report, and a few others I found online:

<100 U/ML ...  NEGATIVE

100-120 U/ML ...  EQUIVOCAL

>120 U/ML ...  POSITIVE

So it seems then that all your results listed below are within Normal ranges:

[BW QUOTE]  
"My test results were:

SSA Autoantibody8 [AU]/mL0 - 99 [AU]/mL
SSB Autoantibody8 [AU]/mL0 - 99 [AU]/mL
Smith Autoantibody33 [AU]/mL0 - 99 [AU]/mL
RNP Autoantibody12 U/ML0 - 99 U/ML
SCL-70 Autoantibody8 [AU]/mL0 - 99 [AU]/mL
JO-1 Autoantibody18 [AU]/mL0 - 99 [AU]/mL
Double Stranded DNA Ab2 iU/mL0 - 99 iU/mL
Centromere antibody5 [AU]/mL0 - 99 [AU]/mL
Histone antibody8 [AU]/mL0 - 99 [AU]/mL

"

I am also curious then as to why your Rheumy suspects Mixed Connective Tissue Disease (MCTD) as opposed to Undifferentiated Connective Tissue Disease (UCTD).  --Do you know why?  Were there other positive tests that specified other Autoimmune issues/diseases/disorders?

Typically, when they don't know, it starts as UCTD, then as specifics are confirmed, it becomes Lupus or MCTD (or any of the many, many autoimmune diseases out there).

Anyway, we are here for ya during this challenging time; just let us know how we can help. :)
Robinj

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 #5 
And keep in mind that no one here is a doctor....
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When the first baby laughed for the first time, its laugh broke into a thousand pieces, and they all went skipping about, and that was the beginning of fairies. [Tinkerbell]
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