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Junior Member
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Hi, I am Male, 28. Recently I have been experiencing needle pain all over my body, hand, leg, stabbing pain on knee, elbow, all these pain are fleeting pain that last only 1 or 2 seconds that come and go once in a few minutes or once in an 1 or 2 hour. Also I experience tension/tightness at the back of my head. This has been almost 2 months already. Recent days, I am also feeling fatigue. So far I don't have rash, no ulcer, blood count check all normal.

But I was tested positive for ANA, below are lab result for ANA

Speckled, titer 1/320 --> anti SS-A, anti SS-B
Possibility : Sjogren's Syndrome, SLE
Cytoplasm granule --> anti ribosomal P protein
Possibility : SLE

Anti ds-DNA 4.0 IU/mL Reference number : 0 - 100

I have consulted with an internal specialist, she said likely I have SLE. But I want to get tested in more specific to confirm it before I started the treatment, I am going to consult further with another internal specialist or Immunology specialist. The Anti ds-DNA still shows negative. Recently I have also been infected with bacteria and also took some strong HIV drug as Post Exposure Phropalaxis (PEP) after potential exposure to HIV, but eventually I am still tested negative for HIV after 3 months. All these symptoms happened after I finish this 1 month drug. I also have twice of hepatitis B vaccination booster, 1.5 month and 2 weeks before the ANA test.

Can anyone tell me does that result on that lab test is confirmative I am positive for SLE ?

I am not sure if the drug/bacteria infection cause me to have positive ANA rather than the SLE ?

I had experience severe stress/anxiety due to potential HIV exposure, I am wondering if this is fibromyalgia ? But my ANA show positive.

I am going to ask for urinalysis for protein/blood, anti-sm test, what else should I ask for ?

Also I only pay for ANA test, but the result also shows that anti SS-A, anti SS-B. Does that mean they also tested positive for anti-SS-A/B ? Does it usually show SS-A and SS-B when we tested for ANA ?


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Senior Contributing Member
Posts: 3,392

Unfortunately, there is no definitive test for lupus. It is dx'd by a combination of labs and symptoms. That is why it has taken some of us years to get a dx. This site can be very helpful:

Also, here is some info on drug induced lupus:

The most common medicines known to cause drug-induced lupus erythematosus are:

  • Isoniazid
  • Hydralazine
  • Procainamide

Other less common drugs may also cause the condition. These may include:

  • Anti-seizure medications
  • Capoten
  • Chlorpromazine
  • Tumor-necrosis factor (TNF) alpha inhibitors (such as etanercept, infliximab and adalimumab)
  • Methyldopa
  • Minocycline
  • Penicillamine
  • Quinidine
  • Sulfasalazine

When the first baby laughed for the first time, its laugh broke into a thousand pieces, and they all went skipping about, and that was the beginning of fairies. [Tinkerbell]

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Senior Contributing Member
Posts: 4,713
Also please keep in mind that there hat having a positive ANA kinda doesn't mean anything. My ANA goes from positive to negative and back to positive. It can be frustrating. Also keep in mind that there are between 60-80 different AI's that mimic lupus.
The bond that links our true family is not one of blood, but one of respect and joy in each other's life

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Senior Contributing Member
Posts: 3,392
You really need to see a Rheumatologist btw...
When the first baby laughed for the first time, its laugh broke into a thousand pieces, and they all went skipping about, and that was the beginning of fairies. [Tinkerbell]

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Active Member
Posts: 50
HI, I have some of ur lab tests results.  My Ana is also 1:320.  I am also - for DNA but + for anti ribosmal P antibodies.  I am undiagnosed as the last rheumatologist I went to said that they are not important. However, other rheumatology books say they are only found in SLE so I'm confused.  I think that ur question of the link between SLE and HIV would best be answered by a skilled immunologist/ hematologist or better yet as RobinJ said a rheumatologist.   Hopefully u have better luck with this than me as I have been trying to get into to c one unsuccesfully.   I really hope whether SLE or not u find an anwser to ur symptoms ! :)   Out of curisoity wat have ur dr's said about the meaning of anti Ribosmal P ?

I am def. not a rheum. But from my experience only I think that these tests can help dx, and I have had some of them but rlly not sure. 

Testing to confirm autoimmune disorder/ immflammation of some type in general: 
- ANA titier (most important) 
- ESR 
- CRP 
-C3, C4

Testing to narrow the specific autoimmune disorder to SLE: 

- DS DNA (diagnostic criteria) 
-Anti SM (diangostic criteria) 
- Anti phosphopholipids (APS, SLE) 
- Anti Chromatin (SLE, Drug induced Lupus ) 
-Anti Histones (SLE, drug induced SLE) 
-Anti ribosomal p antibodies (SLE) 
- Anti RNP (Mixed Connective Tissue Disease, can also be in SLE) 
- Anti SSA/ Anti SSB (Sjogrens, occasionally SLE)

I think that a CBC, urinalysis for proteinuria,  chest x ray may sometimes be abnormal in SLE and can sometimes help satisfy the dx criteria.  

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